GII.17 norovirus re-emerged in the 2020s as a result of dynamic and adaptive evolutionary processes.

ABSTRACT: Over the past two years, increased norovirus activity has been reported in multiple countries, accompanied by a rise in genotype GII.17 prevalence. Despite causing large outbreaks in Asia during 2014-2016, GII.17 has not historically been considered a predominant genotype. In this study, using 1471 archival and newly-identified GII.17 genomes, we investigated (i) global diversification patterns of this virus at the whole-genome level, (ii) in-depth mutational patterns within 511 viruses detected during a 10-year national survey in Germany, and (iii) intra-host viral diversity and adaptation processes that lead to the predominance of the GII.17 virus. The recent GII.17 norovirus exhibited extensive genetic diversity and multiple back-and-forth and recurrent mutations during the early phase

SUBMITTER: Tohma K 

PROVIDER: S-EPMC12749941 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature