Luminal hormone-responsive cells tune the regenerative remodeling of mammary glands in large mammals.

ABSTRACT: The remodeling of mammary glands during pregnancy is essential for initiating lactation. In dairy animals, the overlap of pregnancy and mammary involution triggers a unique process, regenerative remodeling, which is critical for extending lactation duration and enhancing milk production. Unlike the complete regression of lobuloalveolar structures during involution, the regenerative remodeling preserves alveolar structures and promotes rapid mammary gland renewal. However, the cellular and molecular mechanisms underlying such process remain elusive. Here, taking dairy goats (Capra hircus) as a ruminant model, we identified four luminal cell populations through single-cell RNA-sequencing and found a significant reduction in luminal hormone-responsive (LumHR) cells and an increase in luminal

SUBMITTER: Li Y 

PROVIDER: S-EPMC12749961 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature