[He<b>'</b>s Yangchao recipe ameliorates premature ovarian insuffi-ciency by regulating 8-oxoguanine DNA glycosylase 1 in mice].

ABSTRACT:

Objectives

To investigate the molecular mechanism by which He's Yangchao recipe (HSYC) improves ovarian function in a mouse model of premature ovarian insufficiency (POI).

Methods

Forty ICR mice were used to establish a POI model via intraperitoneal injection of cyclophosphamide and were randomly assigned to four groups: model control group, low-dose HSYC group, high-dose HSYC group, and estradiol group (positive control). Additionally, 10 age-matched ICR mice were selected as the blank control group. After intragastric intervention, the ovarian index, serum follicle-stimulating hormone (FSH) levels, and ovarian tissue expression of the FSH receptor (FSHR) were measured. A POI cell model was established by treating the human granulosa tumor cell line with 4-hydroxycyclophosp

SUBMITTER: Hu R 

PROVIDER: S-EPMC12750044 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature