Hypoxia‑mediated Krebs von den Lungen‑6 expression in breast cancer: Implications for tumor invasion and metastasis.

ABSTRACT: Krebs von den Lungen‑6 (KL‑6), a high‑molecular‑weight glycoprotein, is frequently elevated in patients with cancer; however, its precise role in the clinical progression of breast cancer (BC) remains unclear. Tumor hypoxia has been recognized as a critical driver of cancer progression. The present study aimed to investigate the effects of hypoxia on KL‑6 expression and its contribution to the invasive behavior of BC cells. Immunohistochemical analysis of KL‑6 and hypoxia‑inducible factor‑1α (HIF‑1α) was performed in 30 clinical BC tissue samples, and their expression levels were correlated with patient outcomes. BC cell lines (MCF‑7 and MDA‑MB‑231) were used for in vitro analyses, including immunofluorescence, western blotting, wound healing assays, and three‑dimensional spheroid c

SUBMITTER: Ichihara T 

PROVIDER: S-EPMC12750046 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature