[Stem cell therapy for premature ovarian insufficiency: a review of clinical evidence and therapeutic strategies].

ABSTRACT: Premature ovarian insufficiency (POI), characterized by the decline of ovarian function before age 40, significantly compromises fertility and long-term health of patients. Stem cell therapy has emerged as a promising approach for POI. This review synthesizes clinical evidence from studies utilizing cells sourced from adult tissues (e.g., adipose-derived mesenchymal stem cells, bone marrow mesenchymal stem cells and peripheral blood stem cells) as well as from perinatal tissues (e.g., human amniotic epithelial cells and umbilical cord-derived mesenchymal stem cells). Evidence suggests that stem cell transplantation can improve ovarian reserve, reflected by reduced follicle-stimulating hormone levels and increased estradiol and anti-Müllerian hormone levels, with some patients resuming mens

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC12750048 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature