[Association between Y chromosome microdeletions and tes-ticular development in male pediatric patients with congenital reproductive system diseases].

ABSTRACT:

Objectives

To analyze the distribution of Y chromosome azoospermia factor (AZF) microdeletions and their association with testicular development in male pediatric patients with congenital reproductive system diseases.

Methods

A prospective cohort study was conducted on pediatric patients admitted to the Department of Urology of Shanghai Children's Hospital from November 2021 to December 2023. The observation group included boys with hypospadias, cryptorchidism, or disorders of sex development (DSD), while the control group comprised boys with phimosis, indirect inguinal hernia, or hydrocele. Blood samples were collected for AZF microdeletion analysis using multiplex PCR to detect 15 sequence-tagged sites. Testicular ultrasound was performed to record testicular position and

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12750052 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature