Systemic Autoimmune Rheumatic Disease Risk: Association With Long-Term Exposure to Fine Particulate Matter.

ABSTRACT:

Objective

Fine particulate matter (PM_2.5) is a possible trigger of systemic autoimmune rheumatic diseases (SARDs). We investigated SARDs risk related to long-term exposure to PM_2.5 and its components (ammonium, black carbon, mineral dust, sea salt, nitrate, sulfate, organic matter), the composition of which may affect toxicity.

Methods

We assembled an open cohort of Quebec adults (without SARDs) using administrative health data from April 2000 to December 2019. Our SARD case definition included physician billing and hospitalization diagnostic codes for systemic lupus, dermatomyositis, systemic sclerosis, Sjögren disease, and undifferentiated connective tissue disease. Estimates of mean annual PM_2.5 and its components were available from model

SUBMITTER: Geslin M 

PROVIDER: S-EPMC12750135 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature