Probiotic living microneedles designed by interbacterial competition for accelerated infected wound healing.

ABSTRACT: Probiotic therapy offers a promising strategy for chronic infected wound management through pathogen suppression and immune modulation. However, its efficacy remains restricted by weak competitiveness in pathogen-rich niches and poor penetration across biofilm barriers. Inspired by bacterial competitive interactions, we developed a multifunctional microneedle (MN) platform to overcome these limitations. Lactobacillus reuteri (Lr) was coated with poly-l-lysine-modified metal-phenolic networks (MPNs) encapsulating doxorubicin (DOX), yielding DOX@MPN-PLL@Lr (DMP@Lr). The engineered probiotics were incorporated into dissolving MNs enriched with nutrient broth to ensure excellent microneedle performance and probiotic function. This design leverages MPN multifunctionality to reduce early-

SUBMITTER: Wang H 

PROVIDER: S-EPMC12750167 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature