Zeolitic Imidazolate Frameworks Allows for the Thermal Stabilization of Live Viral Vaccine in the Absence of Lyophilization.

ABSTRACT: The impact of vaccines extends beyond the improvement of individual health, significantly lowering the burden of infectious disease in healthcare systems and strengthening the societal infrastructure and economic stability of a nation. Unfortunately, the substantial benefits of vaccines are often disproportionately encountered in affluent nations, with the need for cold-chain logistics heavily contributing to this inequity. Here, we describe the biomimetic mineralization of a live viral vaccine using metal-organic frameworks (MOFs) to alleviate stress caused by ambient temperatures. Utilizing a zinc-based MOF (ZIF-8), we demonstrated the advantages of a higher concentration of the ZIF-8 precursor constituents for coverage of viral antigens and recovery of the live viral Newcastle Disease V

SUBMITTER: Talbot A 

PROVIDER: S-EPMC12750221 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature