Cytosporone B Affects ATP Production of <i>Trypanosoma cruzi</i>: A Lethal Action Investigation.

ABSTRACT: Chagas disease is a neglected parasitic infection spreading worldwide and affecting 8-10 million people, with 14,000 deaths. The treatment is limited to two toxicity nitroheterocycle drugs, approved more than 50 years ago. Considering the urgent need for new therapies, secondary metabolites isolated from endophytic fungi may represent a useful source of bioactive molecules with antiparasitic activity, as described in the literature. In this study, we investigated the anti-Trypanosoma cruzi activity of seven compounds isolated from endophytic fungi present in leaves of the plant Casearia arborea. The compounds dothiorelones A (1), B (2), P (3), and Q (4), cytosporones A (5) and B (6) were isolated from Phomopsis sp. CarGL23, and cytoch

SUBMITTER: Dos Santos AL 

PROVIDER: S-EPMC12750222 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature