Hydroxycarbamide and Sickle Cell Anemia: Paradoxical Effects Related to Redox Mechanisms of Cellular Adaptation.

ABSTRACT: Sickle cell anemia (SCA) is a hemolytic anemia characterized by a chronic redox imbalance with few disease-modifying treatments available. In this study, we aimed to determine the influence of hydroxycarbamide (HC) treatment on the redox mechanisms of cellular adaptation in patients with SCA. We analyzed 10 patients treated (HC+) and 9 not treated (HC-). We evaluated, by RT-qPCR, the transcript levels of the transcription factors NRF2 and ATF4, their modulators (KEAP1, AKT, and PI3K), and the antioxidants (SOD1, CAT, PRDX1, and GPX1). We also collected data on biochemical parameters, including total leukocyte count, direct and indirect bilirubin, lactic acid dehydrogenase (LDH), and fetal hemoglobin (HbF%) levels, by analyzing

SUBMITTER: Santana ILR 

PROVIDER: S-EPMC12750237 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature