An Integrated Approach of Proteomic, Cheminformatic, and In Vitro Drug Screening to Identify Potential Therapeutic Targets of <i>Taenia solium</i> Cysticerci Proteases.

ABSTRACT: Proteases are primary enzymes that are involved in parasites' host invasion by disrupting the physical barriers and immune system. Due to the mass anthelminthic drive against helminths by WHO, the occurrence and spread of drug resistance strains have increased. Taenia solium is one of the major helminthic infections to humans. The CNS infection of parasites' cysts leads to epilepsy, i.e., neurocysticercosis. The existing drugs are several decades old, and their efficacy is poor for the treatment of CNS infection. This demands one to look for new drugs for use in the near future. Detailed proteomic characterization of T. solium proteases is lacking, though they could be one of the primary targets for the development of new drugs. We used LC-MS/MS-based proteomics to characteri

SUBMITTER: Kaur R 

PROVIDER: S-EPMC12750245 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature