Job Loss and Early-onset Dementia Risk in Middle-aged Adults: A Longitudinal Study.

ABSTRACT:

Background

Early-onset dementia poses a significant public health challenge, particularly due to its profound impact on working-age individuals (under 65 years). This study investigated the association between job loss and early-onset dementia in middle-aged adults in Republic of Korea.

Methods

Using National Health Insurance Service data in the Republic of Korea, we analyzed participants aged 45-54 years who were employed by private companies and who underwent health checkups between 2009 and 2010. Early job loss was defined as involuntary unemployment within two years of the 2011 index date. The primary outcome was incident dementia, identified using both International Classification of Diseases-10 (ICD-10) codes and antidementia medication use. Adjusted hazard ratios (HRs

SUBMITTER: Park H 

PROVIDER: S-EPMC12750296 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature