Comparing simultaneous integrated boost whole-brain radiotherapy and local irradiation for brain metastases in lung cancer: A retrospective analysis.

ABSTRACT:

Background

This study aimed to evaluate the differences between simultaneous integrated boost whole-brain radiotherapy (SIB-WBRT) and brain metastases local irradiation efficacy, and determine predictors of outcomes for lung cancer brain metastases patients in therapy.

Methods

This retrospective analysis evaluated patients with brain metastases treated with SIB-WBRT (whole brain at 40 Gy/20 fractions, tumor boosted to 56-60 Gy/20 fractions) and localized irradiation (prescribed doses ranging from 20-60 Gy over 2-25 fractions, typically administered as 30 Gy/5 fractions, with a biologically effective dose [BED] of 28-100.8 Gy) at PUMCH between September 2015 and December 2021. The primary outcome was intracranial progression-free survival (iPFS), with secondary outcomes encom

SUBMITTER: Bi Q 

PROVIDER: S-EPMC12750304 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature