Dysregulation of glycosaminoglycans during oocyte maturation in vitro: Implications for developmental potential.

ABSTRACT: A complex extracellular matrix (ECM) assembles around the mammalian oocyte during maturation and ovulation, comprising hyaluronan as well as proteoglycans. These proteoglycans are hypothesised to carry heparan and chondroitin sulfate side chains. This matrix is essential for ovulation, mediates signalling, and regulates solute diffusion to control the oocyte environment. In vivo, ECM formation is initiated by epidermal growth factor-like peptides released within the follicle, acting together with oocyte-derived growth factors. Although proteoglycans are known components, the specific glycosaminoglycan (GAG) composition remains poorly understood. Here, we characterised GAG abundance in murine cumulus-oocyte-complexes and assessed differences between in vivo and in vitro maturation. The latt

SUBMITTER: Chow DJX 

PROVIDER: S-EPMC12750327 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature