Collaborative Care for Opioid Use Disorder and Mental Illness: The CLARO Randomized Clinical Trial.

ABSTRACT:

Importance

Adults with opioid use disorder (OUD), co-occurring with depression and/or posttraumatic stress disorder (PTSD), may benefit from collaborative care. Although collaborative care is an evidence-based model to treat behavioral health conditions in primary care, it has not been widely tested for OUD with co-occurring mental illness.

Objective

To determine whether collaborative care, tailored for low-resource settings, improves outcomes for patients with OUD and co-occurring depression and/or PTSD more so than enhanced usual care (EUC).

Design, setting, and participants

This 2-group single-masked pragmatic randomized clinical trial was conducted in 18 primary care clinics in California and New Mexico from January 8, 2021, to December 5, 2023, and included adult

SUBMITTER: Watkins KE 

PROVIDER: S-EPMC12750335 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature