Variability in the Universality of Electron Ionization Mass Spectrometry Response to Oxygenates in Complex Environmental Mixtures.

ABSTRACT: Electron ionization mass spectrometry (EIMS) has been widely used to measure complex atmospheric and environmental mixtures. The sensitivity of analytes in EIMS is typically obtained through a multipoint calibration curve using commercially available standards, but many analytes of interest do not have pure compounds available, and many samples contain a large fraction of unidentified compounds. To address these limitations in quantification, those analytes are often calibrated using a small number of standards with chemical similarities (e.g., shared functional groups). However, little systematic data are available on the variability of EIMS response factors to environmental analytes. In this work, we compare the EIMS response with a flame ionization detector (FID), a near-universal detec

SUBMITTER: Kumar P 

PROVIDER: S-EPMC12750400 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature