Source Fingerprinting of PFOA via Full- and Intramolecular Stable Isotope Ratios of Carbon Using Orbitrap-IRMS.

ABSTRACT: Remediation approaches for reducing environmental loading of perfluoroalkyl and polyfluoroalkyl substances (PFAS) require the ability to track PFAS origin sources. One common source attribution method for environmental contaminants is stable isotope analysis, with magnetic sector isotope ratio mass spectrometry (IRMS) being the workhorse for making these measurements. However, relatively large sample requirements and the requisite deconstruction of analytes to simple gases (e.g., CO₂) inhibit the application of IRMS to PFAS in environmental contexts, where even trace PFAS concentrations can exhibit toxicological effects, and decomposition of PFAS yields instrument-degrading HF. To circumvent these limitations, we developed an electrospray ionization Orbitrap-IRMS method to deter

SUBMITTER: Nelson HM 

PROVIDER: S-EPMC12750406 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature