Multifunctional Composite Coating-Enhanced Flexible Microelectrodes for Chronic, High-Fidelity Neural Signal Recording.

ABSTRACT: Implantable flexible neuroelectrodes are critical for brain-computer interface (BCI) applications. However, conventional flexible electrodes often face challenges such as increased electrochemical impedance upon miniaturization, mechanical mismatch with brain tissue, and implantation-induced damage, all of which compromise long-term signal stability and recording quality. Here, we present a multifunctional surface modification strategy to address these limitations. By integrating polycaprolactone/silk fibroin-methacrylate (PCL-SFMA) nanofibers loaded with anti-inflammatory minocycline hydrochloride (MH), nanostructured poly(3,4-ethylenedioxythiophene) (PEDOT) for impedance reduction, and a bioactive SFMA hydrogel layer for seamless neural integration, we developed a composite-coated flexib

SUBMITTER: Pang J 

PROVIDER: S-EPMC12750415 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature