Astrocytes upregulate interleukin-15 in response to neuroinflammation during Alzheimer's disease.

ABSTRACT: BackgroundInterleukin (IL)-15 is a pleiotropic cytokine linked to cognition that is increased in the cerebrospinal fluid of Alzheimer's disease (AD) patients; however, the cellular source of IL-15 and IL-15-sensing cells in AD has not been described.ObjectiveWe sought to determine the cell types responsible for IL-15 secretion in AD and their spatial relationship with amyloid-β (Aβ) pathology.MethodsWe performed immunofluorescent labeling of human postmortem frontal cortex tissue from cognitively intact and dementia patients and used RNA-sequencing and in vitro assays to confirm the stimulus and source of IL-15. We also assessed the hippocampus of 6-7-month-old 5xFAD mice for cytokine levels using multiplex ELISA.ResultsIn the prefrontal cortex of AD patients, we observed increased

SUBMITTER: Shaw BC 

PROVIDER: S-EPMC12750416 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature