Chronic Rhinosinusitis and Autoimmune Diseases: A Comprehensive Large Population-Based Analysis.

ABSTRACT:

Objectives

To evaluate associations between a wide variety of autoimmune diseases and chronic rhinosinusitis without nasal polyposis (CRSsNP), CRS with nasal polyposis (CRSwNP), and the need for endoscopic sinus surgery.

Methods

This is a multicenter retrospective study from January 1, 2010 to July 31, 2025 utilizing data from 106 healthcare organizations in the United States. The TriNetX database was used to identify adult patients over 18 years with a specified autoimmune disease from a comprehensive list that were included in the study. These groups were compared to patients without autoimmune diseases. The evaluated outcomes included the rate of developing CRSsNP, CRSwNP, and the need for endoscopic sinus surgery.

Results

Higher rates of CRSsNP and CRSwNP were not

SUBMITTER: Africa RE 

PROVIDER: S-EPMC12750445 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature