What can claims data tell us about risk factors and survival of patients with hepatocellular carcinoma? Insights from a German population-based study.

ABSTRACT:

Background

Geographic and temporal variations in the incidence and treatment of chronic viral hepatitis and trends in the development of metabolic and behavioral risk factors result in heterogeneous incidences of hepatocellular carcinoma (HCC). Therefore, national epidemiological information should be evaluated to identify the need for action.

Methods

This retrospective observational study included adult patients with incident HCC (2016-2020). A network analysis was performed to investigate inter-relationships among risk factor diagnoses before HCC. Kaplan-Meier method and Cox proportional hazard model were used to analyze survival.

Findings

A total of 2,778 patients were included. Mean age was 71.9 years (SD ±9.7); 69% were male. Most frequently documented risk facto

SUBMITTER: Becht S 

PROVIDER: S-EPMC12750458 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature