Prevalence of DNA Mismatch Repair Deficiencies in Multiple Solid Tumor Types in China.

ABSTRACT:

Aim

Microsatellite instability (MSI) as a result of deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) is a key contributor to the development of tumors with a high mutation rate and cancer-specific neoantigens. dMMR identification can be beneficial for selection of immune checkpoint inhibitor (ICI) therapy-eligible patients. While multiple studies have focused on dMMR prevalence in colorectal cancer (CRC), fewer investigate the prevalence of dMMR in tumor types besides CRC, especially in Chinese patients. In this study, we aimed to determine the prevalence of dMMR in China across five gastrointestinal and gynecological tumor types.

Methods

Tissue samples from Chinese patients with advanced endometrial, ovarian, cervical, biliary tract, or gastric metastatic or unr

SUBMITTER: Shi X 

PROVIDER: S-EPMC12750482 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature