Lobectomy-first versus lymphadenectomy-first on long-term survival for operable non-small cell lung cancer: protocol of LOFTY trial.

ABSTRACT:

Background

The standard surgical treatment for early-stage non-small cell lung cancer (NSCLC) involves anatomical lobectomy and mediastinal lymph node dissection (MLND). According to the principle of "from distal to proximal" during tumour resection, MLND should ideally be performed before lobectomy to fit the criteria of surgical oncology. However, no prospective randomised controlled trial (RCT) has compared MLND-first versus lobectomy-first approaches in early-stage NSCLC. This provides the rationale for this multicentre RCT.

Methods

This multicentre, prospective, open-label, RCT investigates the superiority of MLND-first over lobectomy-first in terms of long-term survival in patients with clinical stage T1-2N0-1M0 (stages I-II) NSCLC (LOFTY study). We plan to enrol 620 p

SUBMITTER: Fan HR 

PROVIDER: S-EPMC12750545 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature