Cholesterol-mediated inflammation activation in alveolar macrophages.

ABSTRACT:

Background

The role of cholesterol- and cholesterol crystal-mediated inflammation has been extensively investigated in circulating macrophages in the context of cardiovascular diseases while little is known about its contribution to lung diseases. However, lipid-laden alveolar macrophages and crystal-like structures have been reported in lungs of different human and animal models of lung diseases. In this study, we address the hypothesis that a mechanism of inflammasome activation, due to altered cholesterol metabolism, may occur also in alveolar macrophages.

Results

We tested the effect of soluble (cholesterol-enriched liposomes) and crystalized cholesterol exposure in a cell model of macrophages and in primary murine alveolar macrophages. Both soluble and crystalized chole

SUBMITTER: Giambelluca S 

PROVIDER: S-EPMC12750553 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature