Environmental greenery and skin cancer risk: a prospective cohort study on incidence and mediating mechanisms.

ABSTRACT:

Background

Skin cancer, including malignant melanoma (MM) and non-melanoma skin cancer (NMSC), is a growing global public health problem. Green spaces are generally beneficial to public health, yet their impact on skin cancer risk remains contentious.

Methods

Using data from 318,738 participants in a large cohort, we examined the association between green space, domestic gardens, and natural environments within 300-m and 1,000-m buffer zones and skin cancer incidence. Hazard ratios (HRs) were estimated using Cox regression. Genetic susceptibility was assessed through polygenic risk scores, susceptible populations were identified through gene-environment interaction, potential biomarkers were discovered through metabolomics, and potential pathways were explored through mediat

SUBMITTER: Qian J 

PROVIDER: S-EPMC12750575 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature