The descriptive epidemiology and projection of liver cancer in adolescents and young adults: findings from the global burden of disease study 2021.

ABSTRACT:

Background

The global burden of liver cancer among adolescents and young adults (AYAs, 15-39 years) is an emerging concern. This study analyzes epidemiological trends from 1990 to 2021 and projects future burden to 2030 to inform prevention strategies.

Methods

Using data from the Global Burden of Disease Study 2021, we calculated age-standardized incidence (ASIR) and mortality (ASMR) rates and disability-adjusted life years (DALYs). Joinpoint regression analyzed temporal trends, and a Bayesian age-period-cohort model projected future burden.

Results

From 1990 to 2021, the absolute number of AYA liver cancer cases and deaths increased. However, ASIR peaked in the early 2000s before declining to 0.82 per 100,000 in 2021, with ASMR falling to 0.65 per 100,000. A sharp de

SUBMITTER: Yang K 

PROVIDER: S-EPMC12750614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature