Distinct gut microbial profile in PIT1 lineage PitNETs: a potential link to cognitive impairment.

ABSTRACT:

Background

Patients with pituitary neuroendocrine tumors (PitNETs) frequently experience cognitive impairment (CI), yet the underlying mechanisms remain poorly understood.

Method

In this study, we assessed cognitive function in 42 PitNETs patients and 42 healthy controls using the Montreal Cognitive Assessment (MoCA), evaluating the effects of tumor volume, invasiveness, pituitary hormone levels, lineage, and surgical intervention.Furthermore, 16S rRNA amplicon sequencing of fecal samples was performed to reveal alterations in gut microbiota composition.

Results

The results demonstrated significantly lower MoCA scores in PitNETs patients compared to controls. Patients with PIT1 lineage tumors exhibited more severe CI than those with SF-1 lineage tumors. Notably, surgi

SUBMITTER: Li J 

PROVIDER: S-EPMC12750663 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature