Global characterization of Dictyostelium discoideum gene and protein expression changes under hypoxic conditions.

ABSTRACT:

Background

Aerobic eukaryotes utilize O₂ to oxidize metabolites and generate ATP. The response to oxygen deprivation leads to migration to locations with more favorable concentrations (aerotaxis), differentiation, metabolic reprogramming, or more global stress responses. In mammals, changes in gene expression are particularly well studied, with the involvement of the Hypoxia-Inducible Factor (HIF-1), which regulates the transcription of hundreds of genes. However, the protist kingdom lacks the HIF-dependent transcriptional response network to adapt to low O₂ levels, and their hypoxic adaptation remains unexplored.

Results

To address the scale and scope of hypoxic responses in protists, we characterized transcriptomic and proteomic changes when the socia

SUBMITTER: Hesnard J 

PROVIDER: S-EPMC12750705 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature