Short-term and long-term reversion rates to normal cognition and their contributing factors among individuals with mild cognitive impairment in a Japanese community: the Hisayama study.

ABSTRACT:

Background

Individuals with mild cognitive impairment (MCI) have a high risk of developing dementia, but some remain cognitively stable or even revert to normal cognition (NC), with reported reversion rates varying widely and inconsistent findings regarding contributing factors. The purposes of this study were to investigate the reversion rate from MCI to NC in a community-dwelling older Japanese population and to identify factors associated with reversion.

Methods

Three community-based surveys of cognitive function were conducted in the town of Hisayama among residents aged 65 years or older in 2012-2013, 2017-2018, and 2022-2023 (participation rate > 92% for each time range). The 5-year reversion rate from MCI to NC was examined using a pooled cohort, combining two cohorts

SUBMITTER: Takabatake K 

PROVIDER: S-EPMC12750711 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature