New insights into mitochondrial segregation from the Doubly Uniparental Inheritance system in bivalves.

ABSTRACT:

Background

While nuclear genome segregation is well characterized, mechanisms underlying mitochondrial partitioning remain partially obscure, even though its failure can cause developmental arrest or harmful mutations. This knowledge gap invokes the need for new, more suitable model systems to study such mechanisms. Doubly Uniparental Inheritance (DUI) of mitochondria in bivalves is a useful system for such studies. In DUI, sperm mitochondria in male embryos are actively transported across cell divisions to precursors of the germline, and this male-specific pattern depends on maternal factors stored in eggs. The presence of distinct mitochondrial segregation patterns in male and female embryos offers a unique opportunity to investigate the molecular bases of this process.

Result

SUBMITTER: Iannello M 

PROVIDER: S-EPMC12750733 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature