Long-term exposure to ambient air pollution and sequential carcinogenesis in the cardia gastric: a cross-sectional study.

ABSTRACT:

Background

Cardia gastric cancer (CGC) is a distinct and increasingly prevalent malignancy, yet the role of air pollution in its sequential carcinogenesis remains unclear. The present cross-sectional study aimed to evaluate the associations between long-term exposure to ambient air pollution and the progression of precancerous cardia gastric lesions.

Methods

A total of 99,493 participants were enrolled from the National Opportunistic Screening Program for Upper Gastrointestinal Cancer in Zhejiang Province of China from 2022 to 2023. Long-term exposure to six air pollutants including particulate matter (PM₁₀), fine particulate matter (PM_2.5), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), ozone (O₃), and carbon monoxide (C

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12750796 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature