LncRNA MIR22HG promotes fracture healing through down-regulation of miR-10a-5p.

ABSTRACT:

Background

Delayed fracture healing (DFH) is a common postoperative complication in fractured patients, impairing affects quality of life and increasing financial burden.

Objectives

This study explored the clinical significance of long noncoding RNA (lncRNA) MIR22HG in DFH and its potential mechanisms in promoting fracture healing.

Methods

A total of 145 patients with normal healing and 132 patients with DFH were enrolled. Quantitative PCR was used to detect the expression levels of MIR22HG, miR-10a-5p, and osteogenic differentiation-related genes. ROC curves and logistic analysis were performed to evaluate the predictive value of MIR22HG. Using the hFOB 1.19 osteogenic differentiation model, the effects of MIR22HG silencing and co-inhibition of MIR22HG and miR-10a-5p

SUBMITTER: He L 

PROVIDER: S-EPMC12750804 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature