Cardiovascular disease risk following radiotherapy among breast cancer survivors: a nationwide cohort study in South Korea.

ABSTRACT:

Background

While radiotherapy (RT) improves breast cancer survival outcomes, concerns persist regarding radiation-induced cardiovascular complications. We aimed to evaluate the incidence and risk of radiation-associated cardiovascular disease (CVD) among breast cancer survivors.

Methods

This population-based retrospective cohort study included 38,045 female breast cancer survivors in South Korea who survived at least 1 year following diagnosis between 2012 and 2019. Cumulative incidence of CVD was estimated using the cumulative incidence function accounting for competing risks. Hazard ratios (HRs) for radiation-associated CVD were calculated using cause-specific Cox proportional hazards models with adjustments for potential confounders.

Results

Among the study populat

SUBMITTER: Lee J 

PROVIDER: S-EPMC12750817 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature