Prenatal exposure to hyperglycemia and child growth trajectories in the first 3 years of life: a prospective birth cohort.

ABSTRACT:

Background

Infants exposed to hyperglycemia in pregnancy (HIP) in utero are known to have higher risks of macrosomia at birth and obesity in adulthood, but longitudinal growth patterns in early childhood remain poorly characterized. This study aimed to examine HIP-associated differences in early childhood growth trajectories.

Methods

In the population-based prospective Jiangsu Birth Cohort (JBC) study, 8780 children (23.3% HIP exposed) were included. Linear mixed models were used to assess the associations of maternal HIP with repeated growth measures in children. Latent class mixed models (LCMM) were used to identify trajectories for weight-for-age (WAZ), length/height-for-age (LAZ) and weight-for-length z-scores (WFL). Models were fitted to the full 0-36-month age range, w

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12750834 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature