Effects of feeding infant formula rich in sn-2 palmitate for 6 months on fecal saponified fatty acids, calcium and stool characteristics: a cluster-randomized controlled trial.

ABSTRACT:

Background

Human milk palmitic acid (PA) is mainly esterified at the sn-2 position of triacylglycerols, while infant formula contains palmitate predominantly in the sn-1/3 positions. Current evidence on long-term health effects of increasing sn-2 palmitate in formula remains insufficient. This study investigated the effects of high sn-2 PA formula (> 40%) on fecal saponified fatty acid, calcium, magnesium and stool characteristics in healthy full-term infants.

Methods

In this cluster-randomized controlled trial, healthy infants < 14 d were assigned to breastfeeding (BF group, n = 66), high sn-2 palmitate formula (sn-2 group, n = 66, 46.3% sn-2 PA) or low sn-2 palmitate formula (control group, n = 67, 10.3% sn-2 PA). Infant demographics, feeding status, stool characteristics,

SUBMITTER: Shen Q 

PROVIDER: S-EPMC12750842 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature