Proinflammatory state and metabolic dysregulation linking delayed feeding progression to extrauterine restricted head growth in extremely preterm infants.

ABSTRACT:

Background

Growth of head circumference is critically associated with neurodevelopmental outcomes. Extrauterine growth restriction of head circumference from birth to term-equivalent age is linked to impaired neurodevelopment. This study examined whether a proinflammatory state and metabolic dysregulation characterize the association between delayed feeding progression and extrauterine restricted head growth in extremely preterm infants.

Methods

This cohort study included infants born ≤ 28 weeks' gestation between 2019 and 2021. Feeding progression trajectories, categorized as improvement or delayed improvement based on daily enteral feeding milk volumes during the first 8 weeks, were analyzed using kmlShape. Plasma metabolomics were assessed at 36 weeks postmenstrual age, a

SUBMITTER: Chen CC 

PROVIDER: S-EPMC12750882 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature