Design, synthesis, and anti-Toxoplasma gondii evaluation of β-carboline derivatives.

ABSTRACT:

Background

The current therapeutic options for toxoplasmosis are limited by side effects. The development of molecules against T. gondii is urgently needed. A series of β-carboline derivatives were synthesized and examined as potential agents against toxoplasmosis.

Methods

A series of β-carboline derivatives were synthesized. To assess their potential as anti-T. gondii agents, cytotoxicity towards Vero cells was determined using the CCK-8 assay. Plaque and qPCR assays were carried out to screen for anti-T. gondii activities, providing insights into their inhibitory effects on the parasite. In vitro assays on T. gondii RH and PRU strains were conducted to evaluate proliferation, invasion, and cyst formation. Transmission electron microscopy was employed to analyze ultrastruct

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12750888 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature