Human and viral chemokines differentially modulate G protein signaling, β-arrestin recruitment and chemotaxis mediated by the viral G protein-coupled receptor ORF74.

ABSTRACT:

Background

Herpesviruses are DNA viruses that establish lifelong latent infections in their hosts. During host-virus co-evolution, several members of the herpesvirus family acquired genes reminiscent of human chemokines and their G protein-coupled receptors (GPCRs), which contribute to immune evasion, viral latency and virus-induced oncogenesis. Open reading frame 74 (ORF74) is the single viral GPCR encoded in the genome of human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV). ORF74 is most closely related to human CXC chemokine receptor 2 (CXCR2), but its signaling properties are quite different given that ORF74 displays high constitutive activity and interacts with both CC and CXC chemokines. Despite many indications that ORF74 plays an importa

SUBMITTER: Kong Q 

PROVIDER: S-EPMC12750907 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature