Dysbiosis of vaginal and peritoneal fluid microbiota in patients with cervical lesions.

ABSTRACT:

Background

This study aimed to characterize disturbances in vaginal microbiota among patients with squamous intraepithelial lesions (SIL) or cervical cancer (CC), and to identify specific bacterial genera with potential as diagnostic or prognostic biomarkers. We also explored microbiota of peritoneal fluid in CC patients across different pathological subtypes.

Methods

A total of 76 participants were enrolled, including 44 SIL and 32 CC patients, further classified into four groups: low-grade SIL (LSIL; n = 14), high-grade SIL (HSIL; n = 30), squamous cell carcinoma (SCC; n = 18) and adenocarcinoma (ADC; n = 14). Vaginal secretions were collected from all participants, and free peritoneal fluid was obtained from 16 SCC and 12 ADC patients. Vaginal HPV status was monitored sem

SUBMITTER: Zhu L 

PROVIDER: S-EPMC12750944 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature