Beyond Comfortable: A Removable Antibacterial Electroconductive Cellulose Nonwoven Dressing for Accelerated Wound Healing.

ABSTRACT: Endogenous bioelectric signals are critical for wound repair by directing keratinocyte migration, proliferation, and differentiation. However, pathogenic infections frequently disrupt this process, particularly in severe wounds. Here, we develop a multifunctional tannin-modified cellulose-polypyrrole nonwoven dressing (TA/Cell@PPy) that simultaneously harnesses epidermal potential-driven electrotherapy and provides antimicrobial protection. The dressing combines tannic acid (TA) for potent antibacterial activity against S. aureus and E. coli with conductive polypyrrole (PPy) that amplifies endogenous electric fields to promote re-epithelialization. In vivo evaluations demonstrate that TA/Cell@PPy significantly accelerates wound closure through three synergistic mechanisms: (1

SUBMITTER: Zhai H 

PROVIDER: S-EPMC12751006 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature