Evaluation of Bifunctional, PSMA-Targeted Triazamacrocycle-Picolinates Compatible with the ¹⁸F/⁴⁴Sc/¹⁷⁷Lu Isotope Triad.

ABSTRACT: The development of matched diagnostic and therapeutic radiopharmaceuticals─theranostic pairs─has emerged as a promising strategy to advance personalized nuclear medicine. However, many current systems rely on chemically distinct elements such as the ⁶⁸Ga³⁺/¹⁷⁷Lu³⁺ pair, leading to inconsistencies in the pharmacokinetics. Here, we evaluate bifunctional chelator platforms derived of triazamacrocycle picolinates, capable of stably incorporating three clinically relevant isotopes ¹⁸F^-, ⁴⁴Sc³⁺, and ¹⁷⁷Lu³⁺. mpatcn supported the formation of [¹⁸F][ScF], [⁴⁴Sc][Sc], and [¹⁷⁷Lu][Lu] complexes when conjugated to a PSMA-targeting peptide (picaga-Met

SUBMITTER: Glaser OM 

PROVIDER: S-EPMC12751015 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature