Penaeus monodon fibrinogen-related lectin interacts with lipopolysaccharide and β-1,3-glucan binding protein to activate the innate immune system.

ABSTRACT: The black tiger shrimp, Penaeus monodon, is cultivated commercially in many countries, including Thailand. However, diseases are major limiting factors in shrimp production. Understanding the shrimp immune responses to pathogens will be essential for health management and disease control. Fibrinogen-related proteins (FREPs) act as pattern recognition receptors by recognizing carbohydrate residues on pathogen surfaces. Here, we report that P. monodon FREP (PmFREP) interacts with the P. monodon lipopolysaccharide and β-1,3-glucan binding protein (PmLGBP) to co-ordinate the innate immune response in shrimp. Like PmLGBP, PmFREP participates in the prophenoloxidase (proPO)-activating cascade upon the Vibrio parahaemolyticus acute hepatopancreatic necrosis disease-causing strain infection. PmFRE

SUBMITTER: Wilasluck P 

PROVIDER: S-EPMC12751051 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature