Combined aerobic and resistance exercise training restores perivascular adipose tissue function in the thoracic aorta of rats with heart failure.

ABSTRACT: Exercise training (ET) is increasingly recognized as a beneficial non-pharmacological intervention for cardiovascular diseases. Our previous results demonstrated that the thoracic perivascular adipose tissue (tPVAT) of heart failure (HF) rats underwent a phenotypic shift from brown to white adipose tissue, accompanied by impaired anticontractile function and oxidative stress. Thus, the present study aimed to investigate the effects of combined aerobic and resistance ET on the vasoactive properties of tPVAT in a HF rat model following myocardial infarction (MI). Wistar rats were subjected to either coronary artery ligation or sham operation (SO). Four weeks after surgery, the rats were divided into four groups: untrained (u) and exercise-trained (t) SO or HF. An 8-week ET program significan

SUBMITTER: Fontes MT 

PROVIDER: S-EPMC12751056 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature