Autoregulation of the MET receptor tyrosine kinase by its intracellular juxtamembrane domain.

ABSTRACT: Receptor tyrosine kinases (RTKs) are single-pass transmembrane receptors whose activation is tightly regulated by intra-domain interactions within both their extracellular and intracellular regions. The intracellular juxtamembrane (JM) domain, which links the transmembrane and kinase domains (KDs), often plays a critical role in modulating kinase activity. The MET receptor, activated by hepatocyte growth factor, requires precise regulation to support normal development and wound healing but becomes a potent oncogene when overexpressed or mutated. A common oncogenic lesion in MET, caused by exon 14 skipping, leads to partial deletion of its unusually long intracellular JM domain and is frequently detected in non-small cell lung cancer, as well as pancreatic, liver, and brain cancers. Despit

SUBMITTER: Linossi EM 

PROVIDER: S-EPMC12751062 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature