Cephalochromin Effects in Triple-Negative Breast Cancer Cells: Apoptosis Induction and Modulation of Survival Pathways.

ABSTRACT: Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of estrogen, progesterone, and HER2 receptors, limiting treatment options due to the lack of targeted therapies. Survivin (BIRC5), an inhibitor of apoptosis (IAP) protein, is overexpressed in TNBC and contributes to tumor progression, chemoresistance, and poor prognosis. Cephalochromin, a fungal-derived bioactive compound, has demonstrated cytotoxic activity in various cancer models; however, its effects on breast cancer remain unexplored. In this study, we evaluated the antineoplastic potential of cephalochromin in breast cancer cells, focusing on its impact on cell viability, apoptosis, cell cycle regulation, and survivin modulation. Cephalochromin exhibited potent cytotoxic effects in TNBC models,

SUBMITTER: Diccini I 

PROVIDER: S-EPMC12751111 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature