Witnessed overdose history and response among overdose survivors who use non-prescribed opioids in an overdose prevention trial.

ABSTRACT:

Background

The REpeated-dose Behavioral intervention to reduce Opioid Overdose Trial (REBOOT) evaluated motivational interviewing for overdose prevention, focusing partly on witnessed overdose response. We assessed participants' witnessed overdose history and REBOOT's impact on overdose response among opioid overdose survivors using non-prescribed opioids in Boston and San Francisco.

Methods

We described participants' witnessed overdose and naloxone administration history over the four months preceding enrollment and the number and characteristics of witnessed overdoses reported during the study. We then used generalized estimating equations to test if the intervention affected if participants responded "me" to who, if anyone, responded to a witnessed overdose by assessing r

SUBMITTER: McCann NC 

PROVIDER: S-EPMC12751120 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature