Feasibility of salivary lipid screening for caries biomarkers in young adults.

ABSTRACT:

Background

To identify distinct lipid metabolic profiles that differentiate young adults with dental caries (DC) from their caries-free (CF) counterparts and to investigate salivary lipid biomarkers indicative of DC status.

Methods

We analyzed salivary lipid profiles from 100 caries-free (CF) and 100 dental caries (DC) college students aged 17-20 years old. Lipidomic analysis was performed using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Data were analyzed using orthogonal partial least squares discriminant analysis (OPLS-DA), variable importance in projection (VIP), and fold change (FC) analysis to identify lipid metabolites that distinguished caries status. Receiver operating characteristic (ROC) curve analysis was performed to c

SUBMITTER: Li Z 

PROVIDER: S-EPMC12751187 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature