Reducing breast biopsy at MRI: comparison of minimum ADC cutoff and mean ADC cutoff identified by the ECOG-ACRIN A6702 multicenter trial.

ABSTRACT:

Background

The aim of this study was to validate the generalisability of the ECOG-ACRIN A6702 multicenter trial identified mean apparent diffusion coefficient (ADC) cutoff (1.53 × 10^- 3mm²/s) and compare its biopsy reduction efficacy against a data-derived ADC minimum (ADC_min) cutoff.

Methods

This dual-cohort retrospective analysis included 453 patients with 494 BI-RADS 4/5 lesions (derivation cohort: 288 patients/311 lesions; validation: 165 patients/183 lesions). ADC_min and mean ADC (ADC_mean) were measured, the data-derived ADC_min cutoff was optimised via an ROC analysis (negative likelihood ratio ≤ 0.1) .Performance metrics included biopsy reduction rates, sensitivity, and false-negative rates, stratified b

SUBMITTER: Wu F 

PROVIDER: S-EPMC12751245 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature