Unraveling the role of the solute carrier family in hepatocellular carcinoma: mechanisms and therapeutic prospects.

ABSTRACT: The solute carrier (SLC) family is one of the largest families of membrane transport proteins, essential for cellular metabolism and communication. Studies have shown that the SLC family plays a critical role in the metabolic processes and intrinsic biological behaviors of hepatocellular carcinoma (HCC). SLC38s contribute to the progression of HCC through signaling pathways such as PI3K/AKT/mTOR and Wnt/β-catenin/MYC. The regulation of upstream factors like miR-10b-5p, the LINC01559-miR-511-SLC38A1 axis, miRNA-432, and other genes are also implicated in HCC development. Additionally, SLC7A11 influences the proliferation of HCC cells via pathways such as SMYD3/SLC7A11 and JAK/STAT/SLC7A11. Other members of the SLC family also play significant roles in HCC through various mechanisms. Given t

SUBMITTER: Xue Y 

PROVIDER: S-EPMC12751257 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature